Mayes McEntire, DMD, MS

Mayes McEntire, DMD, MS

Endodontist in Columbia, SC

Dr. Mayes McEntire grew up in Newberry, South Carolina, and graduated with honors from Presbyterian College. He completed Dental School at the Medical University of South Carolina and then attended The Ohio State University where he received his Specialty Certificate in Endodontics and his Masters of Science.

While at Ohio State, he completed extensive clinical research involving local anesthesia and is committed to providing pain-free endodontic procedures for his patients.

Dr. McEntire returned to South Carolina in 2009 to join Palmetto Endodontics and has performed thousands of endodontic procedures.

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  • The Ohio State University: Certificate in Endodontics and Masters of Science, 2009
  • The Medical University of South Carolina: DMD, 2007
  • Presbyterian College: BS Biology, 2003

Professional History

  • Palmetto Endodontics, LLC, Columbia, SC: Endodontist (2009 – Present)

Professional Organizations/Affiliations


  • Anesthetic Efficacy of 4% Articaine with 1:100,000 Epinephrine versus 4% Articaine with 1:200,000 Epinephrine as a Primary Buccal Infiltration in the Mandibular First Molar Mayes McEntire DMD, MS, John Nusstein DMD, MS, Melissa Drum DMD, MS, Al Reader DMD, MS, Mike Beck DDS, MA. Journal of Endodontics Vol. 37 Issue 4, p.450-454.

Activities & Interests

Dr. McEntire and his family reside in Lexington. When he is not working, he enjoys spending time with his family, playing golf, following college athletics and boating.

Are You Ready for a Great Experience to Save a Tooth and Improve Your Smile?

Contact Dr. McEntire with any questions or to schedule an appointment to improve your oral health today!

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Palmetto Endodontics

no rating out of 5 stars based on 107 Mayes McEntire reviews.

Patient Review

I always heard horror stories about how painful a root canal was. Everyone in the office excelled in easing that anxiety. During the procedure, Dr. McEntire was constantly checking with me to ensure things were going as painless as possible. I hope I don't need another root canal, but if I do it will be performed by Dr. McEntire.

- Mark C

5 out of 5 stars on

Patient Review

Wonderful doctor and staff! Thank you, Dr. McEntire for putting me at ease. You were patient and gentle with someone who was apprehensive about having a root canal. I hope not to need your services again, but if I do, you will be the one I choose.

- Amy H

5 out of 5 stars on

Patient Review

overall experience was great, everyone in the office and doctor made me feel comfortable and my procedure went more smoothly then anticipated. Thank you all for everything!

- Meaghan F

5 out of 5 stars on