Mayes McEntire, DMD, MS

Endodontist in Columbia, SC

Dr Mayes McEntire - Columbia SC Endodontist

Dr. Mayes McEntire grew up in Newberry, South Carolina, and graduated with honors from Presbyterian College. He completed Dental School at the Medical University of South Carolina and then attended The Ohio State University where he received his Specialty Certificate in Endodontics and his Masters of Science.

While at Ohio State, he completed extensive clinical research involving local anesthesia and is committed to providing pain-free endodontic procedures for his patients.

Dr. McEntire returned to South Carolina in 2009 to join Palmetto Endodontics and has performed thousands of endodontic procedures.

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Call Forest Drive Phone Number 803-782-7722 to Schedule Your Appointment!


  • The Ohio State University: Certificate in Endodontics and Masters of Science, 2009
  • The Medical University of South Carolina: DMD, 2007
  • Presbyterian College: BS Biology, 2003

Professional History

  • Palmetto Endodontics, LLC, Columbia, SC: Endodontist (2009 – Present)

Professional Organizations/Affiliations


  • Anesthetic Efficacy of 4% Articaine with 1:100,000 Epinephrine versus 4% Articaine with 1:200,000 Epinephrine as a Primary Buccal Infiltration in the Mandibular First Molar Mayes McEntire DMD, MS, John Nusstein DMD, MS, Melissa Drum DMD, MS, Al Reader DMD, MS, Mike Beck DDS, MA. Journal of Endodontics Vol. 37 Issue 4, p.450-454.

Activities & Interests

Dr. McEntire and his family reside in Lexington. When he is not working, he enjoys spending time with his family, playing golf, following college athletics and boating.

Are You Ready to Discover Your Radiant Smile?

Contact Dr. McEntire with any questions or to schedule an appointment to reclaim your smile today!

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Palmetto Endodontics

5 out of 5 stars based on 64 Mayes McEntire reviews.

Patient Review

I had recently experienced some specific tooth pain. After being diagnosed needing a root canal on 2/24 the attending dentist could not perform the procedure until 3/4, therefore referring me to Palmetto Endodontics. I was given a copy of my diagnosis, referral, and xrays and took them to Palmetto Endodontics on 2/25 and presented them to Emily. She coordinated my scheduling for this procedure with Dr.McEntire and they worked me in the same day. I am not one who looks forward to going to the dentist; however, if I had to go, especially for this procedure, this is the place. They made the entire process a very pleasant experience. My thanks go out to Dr. McEntire, Emily, and the entire staff.

- Dennis H

5 out of 5 stars on

Patient Review

Having a root canal in my mind was going to be a nightmare, but my experience was A-Maze-ing I didn’t have any pain during the entire process. Maze and his staff were outstanding Thanks Maze for the unexpected pleasurable experience.

- Michael Y

5 out of 5 stars on

Patient Review

As a patient in her 70s I had reservations about my first endodontic procedure. However, I was extremely pleased with care provided by Dr. McEntire and the staff at Palmetto Endondontics. The procedure was painless and it was obvious both Dr. McEntire and all staff members were well trained, very experienced, very professional, and the treatment I received was rendered with care and gentleness. It was a good experience and I can highly recommend Palmetto Endodontics to anyone seeking endodontic treatment.

- Suzanne W

5 out of 5 stars on