Mayes McEntire, DMD, MS

Endodontist in Columbia, SC

Dr Mayes McEntire - Columbia SC Endodontist

Dr. Mayes McEntire grew up in Newberry, South Carolina, and graduated with honors from Presbyterian College. He completed Dental School at the Medical University of South Carolina and then attended The Ohio State University where he received his Specialty Certificate in Endodontics and his Masters of Science.

While at Ohio State, he completed extensive clinical research involving local anesthesia and is committed to providing pain-free endodontic procedures for his patients.

Dr. McEntire returned to South Carolina in 2009 to join Palmetto Endodontics and has performed thousands of endodontic procedures.

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Call Forest Drive Phone Number 803-782-7722 to Schedule Your Appointment!


  • The Ohio State University: Certificate in Endodontics and Masters of Science, 2009
  • The Medical University of South Carolina: DMD, 2007
  • Presbyterian College: BS Biology, 2003

Professional History

  • Palmetto Endodontics, LLC, Columbia, SC: Endodontist (2009 – Present)

Professional Organizations/Affiliations


  • Anesthetic Efficacy of 4% Articaine with 1:100,000 Epinephrine versus 4% Articaine with 1:200,000 Epinephrine as a Primary Buccal Infiltration in the Mandibular First Molar Mayes McEntire DMD, MS, John Nusstein DMD, MS, Melissa Drum DMD, MS, Al Reader DMD, MS, Mike Beck DDS, MA. Journal of Endodontics Vol. 37 Issue 4, p.450-454.

Activities & Interests

Dr. McEntire and his family reside in Lexington. When he is not working, he enjoys spending time with his family, playing golf, following college athletics and boating.

Are You Ready to Discover Your Radiant Smile?

Contact Dr. McEntire with any questions or to schedule an appointment to reclaim your smile today!

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Palmetto Endodontics

5 out of 5 stars based on 64 Mayes McEntire reviews.

Patient Review

I was very impressed by my experience with my Doctor and the staff! They made me feel very comfortable and were very accommodating with my schedule! I left feeling that I was well taken care of with my procedure! You were the best! Thank you!

- Melinda K

5 out of 5 stars on

Patient Review

I have seen Dr. Mayes McEntire three times. The first time I was in pain with an infection and couldn't get a dentist to see me immediately but he and his brother Mark did. He is highly professional, knowledgeable, thoughtful, and careful when caring for a patient. Twice I was able to benefit from the fact that his brother Mark is also a dentist and both helped resolved my dental problems. These two great brothers coordinated the best dental service I needed. I felt very secured seeing them both discuss my situation and come up with the best solution. They are both honest and they seem to want to find the most economical and possible solution for dental problems. A year ago I had implants with Mark and was again very pleased with his efficiency and professionalism. I only have positive and praising words for these two professionals. I notice that their clientele has grown considerably, of course, and it may be harder to get appointments with any of them. Their offices are modern, clean, and very well attended by a group of courteous and efficient assistants. I highly recommend them both.


5 out of 5 stars on

Patient Review

I have severe anxiety about dental procedures. Dealing with office closures and scaled back operations amid the COVID 19 crises was not the time to have extreme tooth pain. Dr. McEntire did an emergency consultation and determined I needed a root canal. He and his staff were so professional and compassionate. They explained every step of the procedure and checked on my anxiety level throughout. I had never had a root canal and did not know what to expect. I am petrified of needles and pain, but the whole process was a pleasant surprise. The only discomfort I experienced was the pinch of the initial injection. I highly recommend this great group of professionals!

- Debbie B

5 out of 5 stars on